Mouse Gut Microbiota, Transcriptome, and Metabolome Data Across Six Circadian Time Points

483.7 MB of data supporting a study on obesity-induced colonic inflammation. The dataset includes colon transcriptomes from bulk RNA-seq, gut microbiota profiles from 16S rRNA sequencing, and untargeted fecal metabolomics from LC–MS for male C57BL/6J mice sampled at six circadian time points (ZT0, ZT4, ZT8, ZT12, ZT16, ZT20). It was authored by Zhenting Zhao and last updated on 2026-04-20.

Use Cases

• Identify circadian rhythmicity in gene expression and metabolite levels based on the JTK_CYCLE analysis mentioned in the description
• Perform integrated multi-omics analysis to link gut microbiota rhythms with glutathione metabolism based on the described transcriptome–metabolome integration
• Validate causal relationships in gut-microbiota-host signaling using data from antibiotic depletion and fecal transplantation experiments described
• Analyze histological changes in colon tissue based on the included histology images mentioned in the title

Strengths

• Includes multi-modal data: transcriptomics, 16S rRNA sequencing, metabolomics, and histology images
• Data spans six specific circadian time points (ZT0 to ZT20) for temporal analysis
• File size is 483.7 MB, suggesting substantial data volume

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is from a controlled mouse model (C57BL/6J males), which may limit direct human applicability

Provenance

Source

figshare

Collection Method

Experimental data from mouse models, with sequencing and mass spectrometry analysis.

Time Range

Circadian sampling at ZT0, ZT4, ZT8, ZT12, ZT16, ZT20.

Freshness

Last updated 2026-04-20 08:56:25; freshness should be verified

Geography

Laboratory study; geographic origin is unknown.