Files and scripts used in <b>Pervasive suppressors halt the spread of selfish Segregation

Drosophila melanogaster variant calls and analysis scripts from a 2026 genetics study by Chang, Handler, et al. The dataset includes a 2.4 GB VCF file of SNPs called from the Drosophila Genetic Reference Panel (DGRP) and Iso-1 strains, mapped to the Flybase R6 genome assembly. R scripts for reproducing figures and conducting GWAS analyses are also provided.

Use Cases

• Reproduce genetic analyses and figures from the referenced 2026 study based on the provided R scripts.
• Conduct secondary genome-wide association studies (GWAS) based on the provided variant calls and association study output files.
• Analyze the distribution of Rsp copy number and suppressor frequencies in the DGRP population based on the referenced phenotypic and genotypic data files.
• Study the relationship between Rsp copy number and drive strength based on the data referenced in the figure scripts.

Strengths

• Includes a 2.4 GB VCF file of filtered SNPs generated using the GATK4 best practice pipeline.
• Provides full R scripts for reproducing all main and supplementary figures from the published study.
• Associated files for analyses, such as phenotype and genotype data, are included in the package.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the VCF file is unknown, which may limit suitability assessment.
• The description metadata is limited to file overviews; detailed methodological parameters require consulting the scripts.

Provenance

Source

Amanda Larracuente, associated with the research published in Chang, Handler et al. 2026.

Collection Method

Illumina reads from DGRP and Iso-1 strains were mapped to the Flybase R6 reference using bwa mem, with SNP calling performed in GATK.

Time Range

Data likely corresponds to the DGRP (Drosophila Genetic Reference Panel) and historical datasets referenced up to 2018.

Freshness

Last updated 2026-05-04 16:21:00; freshness should be verified.

Geography

Data is from laboratory strains of Drosophila melanogaster; specific geographic origin is not stated.