Synthetic Data for (+)-Talcarpine and (−)-N4-Methyl,N4-21-secotalpinine Alkaloids

Kamal Prasad Pandey published data on the total synthesis of unnatural macroline-type indole alkaloids on 2026-04-29. The dataset, 416.3 KB in size, likely contains experimental details for the enantiospecific synthesis of (+)-talcarpine and (−)-N4-methyl,N4-21-secotalpinine. The synthesis used an asymmetric Pictet–Spengler reaction and Dieckmann cyclization starting from L-tryptophan, with stereochemistry confirmed by X-ray crystallography.

Use Cases

• Validate synthetic pathways for macroline-type indole alkaloids based on the described Pictet–Spengler/Dieckmann process.
• Analyze stereochemical outcomes based on X-ray crystallography data mentioned in the description.
• Benchmark computational chemistry models against experimental synthesis data for unnatural alkaloids.
• Study the application of DNA-encoded starting materials in total synthesis workflows.

Strengths

• Dataset includes stereochemical confirmation via X-ray crystallography, a high-resolution validation method.
• Synthetic pathway is described in detail, starting from a commercially available compound (L-tryptophan).
• Dataset is published under the CC-BY-NC-4.0 license, specifying clear reuse terms.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (416.3 KB), indicating a limited scope of data.

Provenance

Source

Kamal Prasad Pandey

Collection Method

Data likely originates from laboratory synthesis experiments, including X-ray crystallography analysis.

Freshness

Last updated 2026-04-29 11:35:53; freshness should be verified.