Synthetic Data for (+)-Talcarpine and (−)-N4-Methyl,N4-21-secotalpinine Alkaloids

18.0 MB of data from figshare, authored by Kamal Prasad Pandey, details the total synthesis of unnatural macroline-type indole alkaloids. The work describes an enantiospecific synthesis process starting from L-tryptophan, with stereochemistry confirmed by X-ray crystallography. The dataset was last updated on 2026-04-29.

Use Cases

• Validate synthetic pathways based on the described Pictet–Spengler reaction/Dieckmann cyclization process.
• Study stereochemical outcomes based on X-ray crystallography data of key intermediates.
• Benchmark computational chemistry models against experimental synthesis data for macroline-type alkaloids.
• Design novel indole-based compounds based on the structural features of talcarpine and secotalpinine.

Strengths

• Dataset size is 18.0 MB, indicating a substantial amount of supporting data.
• Stereochemistry was confirmed using X-ray crystallography, a high-resolution validation method.
• The synthesis process is described as starting from commercially available L-tryptophan.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Kamal Prasad Pandey via figshare

Collection Method

Experimental synthesis and analysis, likely containing tabular data from the study.

Freshness

Last updated 2026-04-29 11:35:55; freshness should be verified.