LPZ-51: VbrK Inhibitor Data for Antibiotic Resistance Counteraction

A 619.8 KB dataset from figshare, authored by Bo Jin and last updated in April 2026. It contains data from a fluorescence polarization-based high-throughput screening assay used to identify inhibitors of the Vibrio histidine kinase VbrK. The findings demonstrate a mechanistically distinct antiresistance strategy complementary to existing β-lactam therapies.

Use Cases

• Training models to predict inhibitor efficacy based on fluorescence polarization assay data.
• Analyzing structure-activity relationships for VbrK kinase inhibitors.
• Supporting research on transcriptional regulation of β-lactamase genes.
• Informing the design of combination therapies that potentiate β-lactam antibiotics.

Strengths

• Data is derived from an optimized fluorescence polarization-based screening assay, a quantitative method.
• Includes results from a zebrafish infection model, providing in vivo validation.
• The dataset is focused on a specific, novel target (VbrK) for countering antibiotic resistance.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (619.8 KB), indicating limited scope.

Provenance

Source

figshare, author Bo Jin.

Collection Method

Generated via fluorescence polarization-based high-throughput screening and hit-to-lead optimization.

Time Range

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Freshness

Last updated 2026-04-30 07:04:07; freshness should be verified.

Geography

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