Tolfenamic Acid Polymorph Crystallization Kinetics and Simulation Data

A population balance model simulates the concomitant crystallization of two tolfenamic acid polymorphs. Experimental kinetics were derived from induction time measurements and seeded/unseeded crystallization experiments. The work by Weiwei Tang demonstrates how kinetic modeling can guide polymorph form selection.

Use Cases

• Simulating concomitant crystallization processes based on population balance modeling described in the paper.
• Analyzing polymorph form selection outcomes based on kinetic profiles from induction time measurements.
• Validating crystallization models using experimental data from seeded and unseeded crystallization experiments.
• Exploring attainable polymorph outcomes under various conditions using the described four-quadrant scheme.

Strengths

• The dataset is derived from a published case study focusing on a specific molecular system, tolfenamic acid.
• It integrates both experimental data from crystallization kinetics and simulation results from a developed model.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect a specific experimental and modeling bias inherent to the single case study.

Provenance

Source

Weiwei Tang

Collection Method

Crystallization kinetics uncovered from induction time measurements and seeded/unseeded experiments, with simulation via a developed population balance model.