FBF-VAST: Modulation Mechanism Simulation and Experimental Data for LC × LC

FBF-VAST introduces a valve-assisted modulation technique for two-dimensional liquid chromatography (LC × LC) using a 4-port valve. The dataset includes simulation results from advection–dispersion equations and experimental LC × LC data from red wine sample separation, yielding 27–55 separated peaks. Authored by Pattraporn Chobpradit and last updated in May 2026, the data is shared under a CC-BY-NC-4.0 license.

Use Cases

• Simulating solvent and analyte space–time profiles based on the described advection–dispersion equations.
• Tuning chromatographic selectivity by adjusting valve timing or gradient steepness as described in the mechanism.
• Evaluating method repeatability based on reported peak area %RSDs of 5.28–11.77%.
• Investigating online column cleaning and its impact on column life using the backflushing feature.

Strengths

• Includes both simulation data (advection–dispersion equations) and experimental results from LC × LC runs.
• Reports quantitative performance metrics, including peak area repeatability (%RSD) between 5.28% and 11.77%.
• Demonstrates the method with a concrete application, separating 27–55 peaks of interest from a red wine sample.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• The dataset is relatively small at 7.6 MB, potentially limiting the scope of contained data.

Provenance

Source

figshare

Collection Method

Data generated from simulations of the FBF-VAST mechanism and accompanying LC × LC experiments.

Freshness

Last updated 2026-05-11 15:08:45; freshness should be verified.