Archaster typicus Asterosaponins: Chemical Structures and Cytotoxic Activity

Le Thi Vien's research presents seven asterosaponins isolated from the Vietnamese starfish Archaster typicus. The dataset, last updated on 2026-05-16, includes two new compounds and reports cytotoxic activity against five human cancer cell lines. The data is shared as a 5.3 MB PDF under a CC-BY-4.0 license on figshare.

Use Cases

• Identify new chemical structures based on NMR and mass spectrometry data described in the paper
• Screen for potential anti-cancer compounds based on reported IC50 values against specific cell lines
• Compare chemical profiles of asterosaponins from different starfish species
• Study structure-activity relationships for cytotoxic marine natural products

Strengths

• Includes specific IC50 values for cytotoxicity, ranging from 9.80 ± 0.58 to 13.88 ± 1.01 µM
• Characterizes seven compounds, including two new asterosaponins named archasterosides D and E
• Data is openly available under a permissive CC-BY-4.0 license

Limitations

• The dataset is a 5.3 MB PDF; the underlying structured chemical data is not provided in a machine-readable format
• Row count and column-level documentation are unknown, limiting suitability assessment
• Data may reflect geographic bias inherent to the single source organism from Vietnam

Provenance

Source

Le Thi Vien via figshare

Collection Method

Compounds were isolated using chromatographic separations from a methanol extract and characterized by NMR and HR QTOF mass spectrometry.

Freshness

Last updated 2026-05-16 12:00:03; freshness should be verified.

Geography

Source organism is the starfish Archaster typicus from Vietnam.