Galectin-9 Modulation of Th1/Th2 Balance in Rat Asthma Models

A study investigating the role of Galectin-9 in bronchial asthma using rat models with different airway challenge degrees. Data includes lung tissue damage, inflammatory response, and Th1/Th2 cell ratio measurements from experiments involving gene silencing and overexpression. The dataset was authored by Bin Wu and last updated on 2026-04-23.

Use Cases

• Analyze the correlation between Galectin-9 expression levels and Th1/Th2 cell ratios based on experimental rat models.
• Investigate the effects of Galectin-9 silencing on lung tissue damage and inflammation markers described in the study.
• Model the impact of interleukin-4 overexpression on reversing the therapeutic effects of Galectin-9 inhibition.
• Compare biomarker changes between rat models subjected to different degrees of airway challenge (three vs. six inhalations).

Strengths

• Includes data from controlled experiments with specific group sizes (n=6 per group).
• Analysis methods are specified (ANOVA followed by Tukey's post-hoc test).
• Statistical significance of key findings is reported (P < 0.01).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from a specific animal model, which may limit direct translation to human asthma.

Provenance

Source

figshare

Collection Method

Experimental data from a study establishing rat models of bronchial asthma, with interventions involving adenovirus-mediated gene silencing and overexpression.

Freshness

Last updated 2026-04-23 08:53:18; freshness should be verified.