Gene Alignments and Trees for 865 Genomes from COG2020 Database

Gene trees and multiple sequence alignments for Clusters of Orthologous Groups (COGs) across 865 genomes. The data was generated by aligning ORFs to the COG2020 database using DIAMOND, filtering sequences, and constructing trees with IQ-TREE. The dataset was created by Zhanghan Ni and last updated on 2026-05-14.

Use Cases

• Constructing phylogenetic trees based on gene alignments for COGs.
• Analyzing protein family evolution across 865 genomes using the COG database.
• Benchmarking sequence alignment and tree-building algorithms on filtered, multi-genome data.
• Studying orthologous gene relationships and evolutionary models mentioned in the description.

Strengths

• Data is derived from the authoritative COG2020 database from NCBI.
• Alignments were filtered with specific thresholds (e.g., >15% gap columns removed, sequences with >20% gaps removed).
• Gene trees were built using IQ-TREE with ultrafast bootstraps and a wide range of complex protein evolution models.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset size is 205.6 MB; the specific number of COGs or trees included is not stated.

Provenance

Source

COG2020 database from NCBI.

Collection Method

ORFs from 865 genomes were aligned to COG sequences using DIAMOND, filtered, and gene trees were constructed with IQ-TREE.

Freshness

Last updated 2026-05-14 00:10:09; freshness should be verified.