Mouse Brain Gene Expression and Behavior Under Food Restriction

Gene expression profiles from male C57BL6/J mice across four brain regions following a five-day food restriction, authored by D. J. Guarnieri of Yale University. The dataset includes quantitative PCR validation, plasma corticosterone measurements, and progressive ratio behavioral tests. It was sourced from the paperswithcode platform.

Use Cases

• Identify stress-responsive gene expression patterns in the brain based on whole-genome microarray data.
• Model the relationship between corticosterone levels and motivated feeding behavior based on progressive ratio test results.
• Analyze the time-course of gene expression changes in specific brain regions like the hypothalamus and ventral tegmental area.
• Investigate the dependency of food restriction-induced gene alterations on adrenal gland function using data from adrenalectomized animals.

Strengths

• Data covers four distinct brain regions: medial prefrontal cortex, nucleus accumbens, ventral tegmental area, and hypothalamus.
• Findings are validated using quantitative PCR and plasma corticosterone measurements via ELISA.
• Experimental design includes control conditions with adrenalectomized animals and corticosterone injections.

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Yale University

Collection Method

Whole-genome microarray analysis, quantitative PCR, ELISA, and behavioral testing on laboratory mice.