Genelist_Top 100 human genes up-regulated under hypoxic conditions is a curated list of the top 100 human genes whose expression increases under low-oxygen conditions. The list was compiled by Yoko Ono based on a meta-analysis of existing research. The dataset is available under an Open Access (green) license.
Use Cases
- Prioritizing candidate genes for experimental validation based on meta-analysis evidence of hypoxia response.
- Benchmarking gene expression analysis tools against a known set of hypoxia-responsive genes.
- Investigating potential regulatory pathways and biological processes involved in the hypoxic response.
Strengths
- Focuses on a specific and well-defined biological condition: hypoxia.
- Derived from a meta-analysis, which likely synthesizes evidence from multiple studies.
- List is curated to a specific size of 100 top genes.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- Last update date is unknown; freshness unverified.
Provenance
- Source
- Yoko Ono via paperswithcode
- Collection Method
- Meta-analysis of existing research on gene expression under hypoxic conditions.