Genetic Profiling of Malaria Drug Resistance Markers Across India, 1993-2023

307 Plasmodium falciparum isolates were collected across 14 Indian states between 1993 and 2023, with 243 Pfdhfr and 241 Pfdhps sequences analyzed. The study by Geetika Narang investigates geographic distribution, temporal trends, and molecular evolution of sulfadoxine–pyrimethamine resistance markers. It found that 83% of isolates carried resistant alleles, with double and triple mutants predominating.

Use Cases

• Map geographic distribution of SP resistance based on mutation prevalence across 14 states
• Analyze temporal trends in drug resistance based on samples collected over three decades
• Study molecular evolution and selection pressure based on codon-level mutation analysis
• Assess regional differences in resistance haplotypes to inform treatment policy

Strengths

• 307 field isolates provide a substantial sample size for analysis
• Data spans a 30-year time range (1993-2023) allowing for trend analysis
• Geographic coverage includes 14 Indian states, offering a broad spatial perspective
• Specific mutation frequencies (e.g., S108N at 77.8%) are provided

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic/temporal bias inherent to the sample collection

Provenance

Source

Geetika Narang via figshare

Collection Method

Field isolates characterized by Sanger sequencing, followed by phylogenetic and haplotype network analyses.

Time Range

1993 to 2023

Freshness

Last updated 2026-05-25 07:23:03; freshness should be verified

Geography

14 states across India