Genomic Analyses of ST23 Carbapenem-Resistant Klebsiella Pneumoniae in China, 2019-2023

China's national surveillance system identified 1069 carbapenem-resistant Klebsiella pneumoniae bloodstream isolates from 2019 to 2023. Among these, four ST23-K1 hypervirulent strains were detected, including a nosocomial transmission pair, and analyzed for resistance mechanisms and plasmid transferability. The dataset, authored by Tao Chen and last updated in May 2026, contains supporting genomic analysis files.

Use Cases

• Analyzing the genomic evidence for nosocomial transmission of hypervirulent Klebsiella pneumoniae based on core SNP differences.
• Studying the transferability and evolution of conjugative plasmids carrying carbapenemase genes based on conjugation assay results and plasmid comparative genomics.
• Investigating the correlation between specific plasmid types and antibiotic resistance profiles in clinical isolates.
• Assessing the persistence of hypervirulence in carbapenem-resistant strains based on mouse infection model results and virulence plasmid conservation.

Strengths

• Data is derived from a national surveillance system (BRICS) covering 1069 isolates over a 5-year period (2019-2023).
• Includes detailed genomic analysis of a rare but critical pathogen lineage (0.37% prevalence of ST23-K1).
• Provides specific quantitative results, such as plasmid transfer frequencies (10^-5 to 10^-4) and global plasmid gene carriage statistics (4.4%).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's primary files are in PDF, JPEG, and TIF formats, which may require extraction or manual inspection for structured analysis.

Provenance

Source

figshare

Collection Method

Identified and characterized through China's national surveillance system (BRICS).

Time Range

2019-2023

Freshness

Last updated 2026-05-03 14:00:10; freshness should be verified.

Geography

China