Genomic Epidemiology of MRSA in a Neonatal ICU, 2008-2010

Genomic and epidemiological data from a study of Methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. The dataset includes information on 1940 hospitalized infants, of whom 177 were colonized with MRSA, and features whole-genome sequencing and phylodynamic analysis of selected strains from 2003-2011. The research was conducted by Taj Azarian at the University of Florida.

Use Cases

• Reconstruct MRSA transmission networks based on genomic and patient data.
• Compare virulence and resistance gene profiles between different spa-type strains.
• Analyze patient risk factors associated with MRSA colonization.
• Model the phylodynamic history and effective population size of MRSA genotypes.

Strengths

• Includes data from 1940 patient admissions, providing a substantial cohort.
• Combines genomic sequencing data with patient epidemiological records.
• Covers a multi-year period from 2003 to 2011 for longitudinal analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the genomic data is unknown, which may limit suitability assessment.
• Data may reflect temporal and institutional bias inherent to a single NICU study.

Provenance

Source

University of Florida

Collection Method

Patient screening, spa-typing, and whole-genome sequencing of MRSA isolates.

Time Range

Primary study period 2008-2010, with genomic samples from 2003-2011.

Geography

A single level III neonatal intensive care unit; location unspecified.