GI-00012-2026: Gastric Organoid Gene Expression After Wnt Inhibition

LINDA SAMUELSON published bulk RNA sequencing data on gastric corpus and antral organoid cultures in 2026. The dataset contains differential gene expression analysis results for organoids 24 hours after Wnt inhibition via XAV939 treatment and ligand withdrawal. RNAseq reads and counts data are publicly available in the NIH NCBI Gene Expression Omnibus accession GSE314919.

Use Cases

• Identify Wnt pathway target genes based on differential expression in corpus organoids.
• Compare Wnt signaling responses between gastric corpus and antrum regions.
• Validate organoid models for gastrointestinal research using transcriptomic data.
• Integrate gene expression results with other datasets from the Gene Expression Omnibus.

Strengths

• Data is associated with a published manuscript in American Journal of Physiology: Gastrointestinal and Liver Physiology.
• Raw RNAseq reads and counts are publicly archived under accession GSE314919.
• Differential analysis identified 2082 DEGs in corpus and 2588 DEGs in antrum organoids.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to a single time point (24 hours) after a specific Wnt inhibition protocol.

Provenance

Source

LINDA SAMUELSON via figshare.

Collection Method

Bulk RNA sequencing (RNAseq) on gastric corpus and antral organoid cultures after Wnt inhibition.

Time Range

Data corresponds to a 24-hour post-treatment measurement.

Freshness

Last updated 2026-05-06 16:02:59