Ginsenoside Rg1 Effects on Human Microglial Cells for Parkinson's Disease Research

Experimental data from a study investigating the anti-inflammatory effects of ginsenoside Rg1 on the human microglial cell line HMC3. The dataset, shared by Zheyao Ni on figshare under a CC-BY-4.0 license, includes measurements of cytokine production, cell viability, apoptosis, signaling pathways, oxidative stress, and mitochondrial function. It was last updated on April 22, 2026.

Use Cases

• Analyze the relationship between ginsenoside Rg1 pretreatment and pro-inflammatory cytokine levels based on TNF-α, IL-1β, and IL-6 measurements.
• Model the effect of Rg1 on cell viability and apoptosis under LPS-induced inflammatory stress.
• Investigate the suppression of the TLR4/NF-κB/MAPK signaling pathway by Rg1 based on described signaling data.
• Assess the impact of Rg1 on oxidative stress markers based on ROS, MDA, and SOD activity levels.
• Evaluate improvements in mitochondrial function based on mitochondrial membrane potential and ATP production data.

Strengths

• Data is focused on a specific, well-defined experimental model using the HMC3 human microglial cell line.
• The dataset measures multiple interrelated biological endpoints, including cytokines, signaling, oxidative stress, and mitochondrial function.
• It is shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 12.5 KB, indicating limited scope.

Provenance

Source

figshare, author Zheyao Ni.

Collection Method

Laboratory experiment on HMC3 cells exposed to LPS and treated with ginsenoside Rg1.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-22 15:25:44; freshness should be verified.

Geography

Geographic origin of the research is not specified.