Glimepiride Effects on Blood-Brain Barrier and Neuroinflammation in ICH Mouse Model

A research dataset from figshare details a study on the neuroprotective effects of Glimepiride in a mouse model of intracerebral haemorrhage. The dataset, authored by Huizhen Zhou and last updated in 2026, includes results from neurological function tests, brain tissue analyses, and protein expression measurements. The study involved C57BL/6 mice treated with Glimepiride for 3 days following induced ICH.

Use Cases

• Analyzing the relationship between Glimepiride treatment and neurological function scores based on corner turn, forelimb placing, and modified Garcia tests.
• Investigating protein expression changes (e.g., ZO-1, occludin, MMP-9) related to blood-brain barrier integrity following ICH.
• Studying markers of neuroinflammation and apoptosis (e.g., Iba-1, myeloperoxidase, BCL-2, BAX) in brain tissue post-ICH.
• Correlating treatment outcomes with measures of brain edema and hematoma volume reduction.

Strengths

• The dataset is associated with a detailed experimental protocol involving specific mouse strains (C57BL/6), treatment dosage (4 mg/kg/day), and a defined time course (3 days).
• Multiple outcome measures are described, including neurological function tests, protein expression via Western blot, and histological analyses like immunohistochemistry and TUNEL staining.
• The data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small (227.0 KB), suggesting it contains primarily textual documentation (DOCX) rather than extensive raw or processed data tables.
• Row count and column-level documentation are unknown, which limits assessment of the data's structure and suitability for computational analysis.
• The description metadata is detailed for the study but does not specify the format or granularity of the underlying numerical or image data files.

Provenance

Source

figshare, author Huizhen Zhou

Collection Method

Experimental data from a controlled laboratory study on mice with induced intracerebral haemorrhage.

Freshness

Last updated 2026-04-28 07:00:23