Global Collagen PTM Atlas of Mice Tissues Across 25 Organs

39 of 44 annotated collagen chains were identified across 25 mouse tissues, mapping over 4,800 unique post-translational modification sites. The atlas separates soluble and insoluble extracellular matrix fractions, providing state-resolved modification landscapes at site-level resolution. Author Trayambak Basak published this 13.5 GB resource under CC-BY-4.0 on figshare in May 2026.

Use Cases

• Compare collagen hydroxylation and glycosylation patterns based on tissue- and fraction-specific modification landscapes
• Analyze regulated collagen processing based on conserved core versus distinct tissue-specific PTM sites
• Investigate collagen cross-linking preparation based on inverse glycosylation patterns between insoluble and soluble ECM fractions
• Study matrix assembly and tissue specialization in development, aging, and disease based on the pan-tissue, state-resolved PTM reference framework

Strengths

• Covers 25 distinct mouse tissues, providing broad biological coverage
• Maps 2704 4-hydroxyproline, 1133 3-hydroxyproline, 807 hydroxylysine, and 230 glycosylated lysine unique sites
• Separates data into soluble and insoluble extracellular matrix fractions for state-resolved analysis
• Large dataset at 13.5 GB, suggesting substantial depth of measurement

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is specific to mouse tissues, limiting direct applicability to human studies

Provenance

Source

figshare

Collection Method

Generated by building on a previously published mouse ECM atlas, separating soluble and insoluble fractions.

Freshness

Last updated 2026-05-25 11:28:00