Nanostructured Lipid Carrier Data for Psoriasis Drug Delivery

Amit Sharma's research dataset on figshare, last updated April 28, 2026, details the development of glycolic acid-integrated nanostructured lipid carriers (NLCs) co-delivering apremilast and quercetin. The dataset includes physicochemical characterization data such as particle size (121.75 ± 9.18 nm), polydispersity index, and zeta potential, along with results from in-vitro drug release, skin permeation, cytocompatibility, antioxidant, and anti-inflammatory assays. These data support the evaluation of a novel topical nanocarrier formulation intended for psoriasis management.

Use Cases

• Modeling nanoparticle formulation stability based on particle size, PDI, and zeta potential measurements
• Analyzing sustained drug release profiles for topical nanocarriers mentioned in the description
• Evaluating anti-inflammatory efficacy based on cytokine (IL-6, TNF-α) inhibition data from LPS-stimulated macrophages
• Assessing skin safety and irritation potential using HET-CAM assay results described in the study

Strengths

• Dataset includes specific, reported physicochemical measurements like a particle size of 121.75 ± 9.18 nm and a zeta potential of −35.77 ± 3.44 mV
• Description details multiple evaluation methods, including in-vitro drug release, ex-vivo skin permeation, and cytocompatibility via MTT assay
• Results from specific anti-inflammatory assessments, such as the reduction of pro-inflammatory cytokines IL-6 and TNF-α, are provided

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (1.6 MB), which may indicate limited scope or number of observations

Provenance

Source

figshare

Collection Method

Experimental data from the development and optimization of nanostructured lipid carriers using a 3^4 Central Composite Design.

Freshness

Last updated 2026-04-28 09:16:26; freshness should be verified