Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow

120 nm hydrodynamic diameter and -60 mV ζ-potential characterize the gold-modified SPIONs analyzed in this study. The dataset, authored by Hatice Genç and last updated in April 2026, includes in vitro and in vivo toxicity evaluations in human cells and chick embryos, as well as magnetic accumulation data under flow conditions. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Assessing nanoparticle biocompatibility based on in vitro toxicity data for human umbilical vascular endothelial cells (HUVECs) and primary human fibroblasts.
• Modeling magnetic accumulation of nanoparticles under arterial-like flow conditions based on the described in vitro and in silico studies.
• Evaluating dose-dependent toxicity for biomedical applications based on the reported toxic thresholds in cells and chick embryos.

Strengths

• Includes specific quantitative measurements: hydrodynamic diameter of 120 nm and ζ potential of -60 mV at pH 7.
• Reports concrete toxicity thresholds: well-tolerated by fibroblasts up to 25 µg Fe/mL but toxic to HUVECs at ≥10 µg Fe/mL.
• Provides in vivo toxicity results from chick embryo experiments with a specified dose of 45 µg.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data files are in DOCX and PPTX formats, which may require conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory experiments analyzing nanoparticle properties and biological effects.

Freshness

Last updated 2026-04-20 09:20:08; freshness should be verified.