GPR19 Role in p53-Mutant Breast Cancer: Gene Expression and Signaling Data

A 17.3 MB dataset from figshare, published under CC-BY-4.0 by Jihan Qiu and last updated in April 2026. It contains results from a study investigating the orphan receptor GPR19 as an oncogenic driver in TP53-mutant breast cancer. The data likely includes gene expression levels, cell proliferation metrics, and signaling pathway activation from public datasets, clinical samples, cell models, and xenograft experiments.

Use Cases

• Identify prognostic biomarkers for breast cancer based on GPR19 expression levels mentioned in the description.
• Model cell cycle regulation in cancer based on data concerning CCNB1 and PLK1 activation.
• Investigate signaling pathway crosstalk based on the described link between GPR19, ERK phosphorylation, and FOXM1 expression.
• Validate therapeutic targets in triple-negative breast cancer based on in vivo tumor growth suppression data.

Strengths

• Dataset size is 17.3 MB, indicating a manageable download and processing scale.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• Data integrates multiple experimental sources mentioned, including RNA sequencing, clinical samples, and xenograft models.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Analysis of public datasets, clinical samples, breast cancer cell models, RNA sequencing, ERK rescue experiments, and xenograft models.

Time Range

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Freshness

Last updated 2026-04 27 14:08:26; freshness should be verified.

Geography

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