GPR3 Ligands Discovered via Virtual and Biosensor Screening

GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening is a dataset from figshare, authored by Hannes Schihada and last updated on 2026-05-07. It contains results from a screening campaign that identified new drug-like ligands for the GPR3 receptor, a therapeutically relevant G protein-coupled receptor. The dataset is stored in an XLSX file with a size of 27.8 KB.

Use Cases

• Training ligand-activity prediction models based on the identified GPR3 ligands.
• Benchmarking virtual screening methods against the experimental biosensor results described.
• Analyzing structure-activity relationships for GPR3 based on the discovered compound series.
• Developing blueprint screening strategies for other orphan GPCRs based on the described sensor approach.

Strengths

• Dataset is associated with a published scientific methodology combining virtual screening and a novel conformational biosensor.
• Includes at least one ligand (compound 33) with reported potency in the nanomolar range.
• Released under a specific open license (CC-BY-NC-4.0) with clear authorship.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (27.8 KB), indicating limited scope, likely containing summary results rather than raw screening data.

Provenance

Source

Hannes Schihada via figshare.

Collection Method

Data generated through combined virtual compound screening against GPR3 homology models and experimental high-throughput screening using a conformational GPR3 biosensor.

Time Range

null

Freshness

Last updated 2026-05-07 19:11:17; freshness should be verified.

Geography

null