G-CSF for Heart Attack: Meta-Analysis of 11 Randomized Trials and 1,073 Patients

A systematic review and meta-analysis synthesizing results from 11 randomized controlled trials involving 1,073 patients, investigating the use of Granulocyte Colony-Stimulating Factor (G-CSF) for acute myocardial infarction. The analysis, authored by Luiz Guilherme Silva Almeida and updated in April 2026, compares G-CSF against placebo or standard care. Primary outcomes measured include left ventricular end-diastolic volume, left ventricular end-systolic volume, and left ventricular ejection fraction.

Use Cases

• Analyzing treatment effects on cardiac structure based on left ventricular volume measurements.
• Comparing imaging modality outcomes (echocardiography vs. MRI) for a therapeutic intervention.
• Evaluating clinical safety and efficacy based on secondary outcomes like mortality and reinfarction rates.
• Training models for systematic review data extraction and result aggregation from randomized controlled trials.

Strengths

• Includes data from 11 randomized controlled trials, a recognized gold standard study design.
• Encompasses 1,073 participant records, providing a substantive sample size for analysis.
• Reports specific quantitative outcomes with mean differences and confidence intervals (e.g., LVEDV MD: -4.39 mL).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description notes discrepancies between echocardiography and MRI findings, suggesting potential measurement heterogeneity.

Provenance

Source

figshare

Collection Method

Systematic search of PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials.

Time Range

Temporal coverage of the included trials is not specified.

Freshness

Last updated 2026-04-17 07:39:32; freshness should be verified.

Geography

Spatial coverage of the included trials is not specified.