Nf1 +/- Mouse Model: Behaviour, Brain Size, and Gut Microbiome Data

Sonali Reisinger's dataset contains behavioural, anatomical, and gut microbiome data from a heterozygous germline knockout mouse model (Nf1 +/-) of Neurofibromatosis type 1. It includes in-depth behavioural evaluations, brain weight measurements, and gut microbiota composition derived from full-length 16S rRNA sequencing. The data reveals sex-dependent associations between gut microbiome alterations and increased relative brain size in the Nf1 +/- model.

Use Cases

• Analyzing correlations between gut microbiome composition (e.g., Clostridium, Blautia abundance) and brain size in a genetic mouse model.
• Comparing behavioural phenotypes (learning, memory, social interaction, anxiety) between Nf1 +/- and wild-type control mice.
• Investigating sex-dependent differences in host-microbial signatures linked to neurodevelopmental conditions.
• Examining alterations in specific metabolic pathways, such as pyrimidine deoxynucleotide biosynthesis, in relation to genotype.

Strengths

• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Includes multimodal data from a single experimental model: behavioural assays, anatomical brain measurements, and full-length 16S rRNA microbiome sequencing.
• Findings are directly relevant to clinical NF1 and preclinical autism research, as noted in the description.

Limitations

• Column names and a precise row count are not provided, limiting understanding of the data structure.
• The dataset size (60330) is given but its unit (likely bytes) and relation to rows/columns is unclear.
• Metadata is sparse, lacking organizational affiliation and a complete column schema.

Provenance

Source

Sonali Reisinger

Collection Method

Data generated from behavioural evaluations, anatomical studies, and full-length 16S rRNA sequencing of gut microbiota in a Nf1 +/- mouse model.

Time Range

null

Freshness

Last updated on 2026-03 24.

Geography

null