PGC MDD2025: Genome-Wide Summary Statistics for Major Depression

GWAS summary statistics from the Psychiatric Genomics Consortium's 2025 meta-analysis of major depression across multiple ancestries and phenotype definitions. The 4.9 GB release includes separate files for European and multi-ancestry cohorts, clinical, questionnaire, and electronic health record phenotypes. Data is provided in multiple standard formats including GWAS-SSF and daner.

Use Cases

• Conducting polygenic risk score analysis based on summary statistics for major depression.
• Performing meta-analysis of depression genetics using the provided multi-ancestry and European-specific results.
• Investigating genetic correlations between depression subtypes based on clinical versus questionnaire phenotypes.
• Benchmarking new GWAS methods against this large, consortium-produced meta-analysis.

Strengths

• Data is from the authoritative Psychiatric Genomics Consortium, a major collaborative effort.
• Provides 4.9 GB of summary statistics across multiple phenotype definitions and ancestry groups.
• Released under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analyses.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Psychiatric Genomics Consortium (PGC)

Collection Method

Meta-analysis of genome-wide association studies.

Freshness

Last updated 2026-05-27 09:27:23; freshness should be verified.

Geography

Multi-ancestry and European-specific cohorts.