Mouse Vestibular Function GWAS in the Hybrid Mouse Diversity Panel

Genome-wide association study summary statistics link approximately 100,000–160,000 SNPs to vestibular function phenotypes across young and aged mice. Data from the Hybrid Mouse Diversity Panel includes results for vestibular sensory evoked potential thresholds, amplitudes, and balance beam traversal times. Association testing used FaST-LMM linear mixed models with a leave-one-chromosome-out approach to account for population structure.

Use Cases

• Identifying genetic variants associated with vestibular threshold sensitivity based on SNP-level p-values and effect sizes.
• Comparing genetic architecture of balance traits between young female and aged male/female mouse cohorts.
• Prioritizing candidate genes for inner ear disorders using chromosome and genomic position data.
• Replicating or meta-analyzing findings using standardized GWAS summary statistics columns.

Strengths

• Covers five distinct vestibular phenotypes across two age cohorts, providing a comparative view.
• Analysis accounts for population structure using a leave-one-chromosome-out kinship matrix method.
• Data is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Key metadata like exact row counts, file sizes, and a complete column list are unavailable.
• The dataset's future update date (2026-03-24) suggests it may not yet be publicly released or is a placeholder.
• Column availability is noted as 'depending on availability', indicating potential inconsistency across files.

Provenance

Source

Yuzuru Ninoyu

Collection Method

GWAS performed using FaST-LMM on genotypes from the Mouse Diversity Array, with phenotypes from vestibular evoked potentials and balance beam assays.

Time Range

Phenotypes measured in mice aged 6 weeks and 22 ± 2.5 months.

Freshness

2026-03-24

Geography

null