FBXO31-Dependent Protein Degradation Assay Data for Small-Molecule Recruiters

A 252.1 KB Excel dataset from figshare, last updated on April 11, 2026, by author Chenlu Zhang. It contains data related to establishing FBXO31 as a targetable E3 ligase for degrading proteins like FKBP12, kinases, and BET proteins using small-molecule recruiters. The dataset likely contains results from mechanistic studies on ternary complex formation and key residue identification.

Use Cases

• Training models to predict small-molecule efficacy based on FBXO31 engagement data mentioned in the description.
• Analyzing structure-activity relationships for amidated Ala-Phe motif recruiters described in the study.
• Benchmarking degradation potency for targets like FKBP12, kinases, and BET proteins (BRD2, BRD3, BRD4) referenced in the description.

Strengths

• Dataset is shared under a specific open license (CC-BY-NC-4.0).
• File size is precisely documented as 252.1 KB.
• Last update timestamp is explicitly provided (2026-04-11 02:43:44).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Freshness

Last updated 2026-04-11 02:43:44; freshness should be verified.