FBXO31-Dependent Degradation Assay Data for Protein Targets

Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation is a dataset from figshare, authored by Chenlu Zhang and last updated in April 2026. It contains experimental data on establishing FBXO31 as a TPD-competent E3 ligase and its use in degrading targets like FKBP12, kinases, and BET proteins. The dataset is stored in an XLSX file and is approximately 1 MB in size.

Use Cases

• Training models to predict small-molecule degrader efficacy based on chemical recruiter motifs.
• Analyzing ternary complex formation between FBXO31, recruiters, and target proteins.
• Validating mechanistic models of E3 ligase engagement using key residue data.
• Screening for new degrader candidates against kinases and BET protein targets.

Strengths

• Dataset is approximately 1 MB, indicating a focused and manageable size for analysis.
• Includes mechanistic validation data on ternary complex formation and key residues in FBXO31.
• Covers multiple protein target classes, including FKBP12, kinases, and BET proteins (BRD2, BRD3, BRD4).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental assay data from mechanistic studies of targeted protein degradation.

Freshness

Last updated 2026-04-11 02:43:43; freshness should be verified.