FBXO31 E3 Ligase Degradation Data for FKBP12, Kinases, and BET Proteins

Chenlu Zhang published this dataset on figshare in April 2026. It contains data on establishing FBXO31 as a targetable E3 ligase for protein degradation. The research demonstrates the degradation of targets including FKBP12, multiple kinases, and BET proteins BRD2, BRD3, and BRD4.

Use Cases

• Training models to predict degrader efficacy based on chemical recruiter motifs.
• Analyzing ternary complex formation mechanisms for FBXO31-mediated degradation.
• Screening small-molecule binders for conversion into FBXO31-dependent degraders.

Strengths

• Dataset is 1.6 MB in size, indicating a focused and manageable download.
• Data is associated with a specific, peer-reviewed research strategy for targeted protein degradation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last updated 2026-04-11 02:43:49; freshness should be verified.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from mechanistic studies on protein degradation.

Freshness

Last updated 2026-04-11 02:43:49.