FBXO31 Degrader Data for FKBP12, Kinases, and BET Proteins

Chenlu Zhang published this dataset on figshare in April 2026. It contains data on establishing FBXO31 as a targetable E3 ligase for protein degradation. The research demonstrates the degradation of FKBP12, multiple kinases, and BET proteins BRD2, BRD3, and BRD4 using small-molecule recruiters.

Use Cases

• Train models to predict degrader efficacy based on chemical recruiter motifs mentioned in the description.
• Analyze structure-activity relationships for FBXO31-dependent degraders described in the study.
• Identify key residues in FBXO31 required for target degradation as detailed in the mechanistic studies.

Strengths

• Data is associated with a specific, peer-reviewed research finding on FBXO31 as a TPD-competent E3 ligase.
• Dataset is available in a structured XLSX format with a size of 1.5 MB.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific research methodology.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from mechanistic studies on protein degradation.

Freshness

Last updated 2026-04-11 02:43:48; freshness should be verified.