FBXO31 Degrader Dataset for Targeted Protein Degradation

FBXO31 is established as a TPD-competent E3 ligase recognizing C-terminal amide-bearing degrons. The dataset, shared by Chenlu Zhang on figshare, contains experimental data on small-molecule degraders targeting proteins like FKBP12, kinases, and BET proteins. It was last updated on April 11, 2026.

Use Cases

• Train models to predict degron recognition based on chemical recruiter motifs.
• Analyze ternary complex formation for FBXO31-mediated degradation.
• Screen for new small-molecule binders that can be transformed into FBXO31-dependent degraders.
• Study structure-activity relationships for degraders targeting kinases and BET proteins.

Strengths

• Data is shared under a specific CC-BY-NC-4.0 license, clarifying reuse terms.
• The description details a specific biological mechanism involving FBXO31 and C-terminal amide recognition.
• File is provided in the structured XLSX format, suitable for tabular analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 379.1 KB, indicating limited scope.

Provenance

Source

Chenlu Zhang via figshare.

Collection Method

Likely contains experimental results from mechanistic studies on protein degradation.

Freshness

Last updated 2026-04-11 02:43:46; freshness should be verified.