Rat Model Data on Intracranial and Intraocular Pressures for Spaceflight Vision Changes

A ground-based animal study from NASA investigates visual system changes observed in astronauts. The program used the rat hindlimb suspension model to examine the relationship between cephalic fluid shifts and intracranial/intraocular pressure regulation, as well as effects on visual structure and function. Data includes continuous biotelemetry, tonometry measurements, MRI images, and ophthalmic examinations from both male and female subjects.

Use Cases

• Modeling the relationship between cephalic fluid shifts and intracranial pressure based on continuous biotelemetry data.
• Analyzing sex differences in visual system responses to simulated microgravity conditions.
• Studying the effects of aging and hypercapnia on intraocular pressure and retinal morphology.
• Developing predictive models for astronaut visual changes using MRI-derived visual system morphology.

Strengths

• Includes both male and female subjects to examine sex differences.
• Combines multiple data modalities: continuous biotelemetry, tonometry, MRI, and ophthalmic exams.
• Examines contributory factors of aging and elevated atmospheric carbon dioxide (hypercapnia).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from a ground-based rat hindlimb suspension model, with chronic instrumentation and regular measurements.

Time Range

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Freshness

Last updated 2026-03-13 20:10:32.249957; freshness should be verified.

Geography

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