Hepitopes: HLA Class I Epitopes in Hepatitis B Virus from Literature Review

A systematic literature review performed in January 2016 identified and curated known and putative HLA Class I epitopes in hepatitis B virus. The review searched Medline from 1946-2016 and Embase from 1974-2016, with each citation reviewed by a primary and secondary expert. The dataset is intended as a growing resource for virologists, immunologists, and vaccine designers, with a live interactive version available online.

Use Cases

• Identify potential T-cell targets for HBV vaccine design based on curated epitope locations.
• Study the relationship between HBV protein regions and HLA Class I binding based on literature evidence.
• Validate computational epitope prediction models against a manually reviewed set of known epitopes.

Strengths

• Systematic review methodology with searches across two major databases (Medline and Embase) over long time ranges.
• Dual-expert review process for each citation to ensure record accuracy.
• Epitope locations are mapped to a published reference HBV strain for consistency.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The literature review snapshot is from January 2016; newer discoveries are not included in this static version.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Sheila Lumley, associated with the University of Oxford.

Collection Method

Systematic literature review of Medline and Embase via OVID, plus bibliography searches.

Time Range

Literature review covers Medline (1946-2016) and Embase (1974-2016), performed in January 2016.

Freshness

Last update date is unknown; the static version corresponds to the point of initial publication.