High-Throughput Proteomics in Lymphangioleiomyomatosis: Premelanosome Protein as a Diagnos

Approximately 10,000 plasma proteins measured in 20 patients with lymphangioleiomyomatosis and 10 healthy controls using the SomaScan assay. The dataset includes results identifying 662 differentially expressed proteins and a validated 6-protein diagnostic score (LAMScore) with 100% specificity. Author Rémi Diesler published the data on figshare in May 2026.

Use Cases

• Validate the 6-protein LAMScore diagnostic model based on the identified protein panel.
• Investigate the role of neutrophil degranulation pathways in disease pathogenesis based on enriched protein signatures.
• Compare plasma levels of premelanosome protein (PMEL) and matrix metalloproteinase 8 (MMP8) between patient and control cohorts.
• Develop machine learning models for disease classification using the approximately 10,000 measured protein features.

Strengths

• Proteomic analysis measured approximately 10,000 plasma proteins per sample.
• Validation cohort included a total of 53 patients and 64 control participants.
• The derived 6-protein diagnostic score achieved an area under the ROC curve of 0.997.
• Key findings, like MMP8 elevation to 662 pg/mL in patients, were confirmed by ELISA.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The initial discovery cohort is relatively small with 20 patients and 10 controls.

Provenance

Source

figshare

Collection Method

High-throughput proteomic SomaScan assay and ELISA validation.

Freshness

Last updated 2026-05-05 08:33:01; freshness should be verified.