HK97-Fold Proteins: Evolutionary Analyses of Viral Capsid Sequences and Structures

HK97-fold proteins evolutionary analyses provides sequence- and structure-based resources supporting the study of major capsid proteins and encapsulins. The dataset includes FASTA sequences, phylogenetic trees, protein structure models, and identifier lists from viruses, encapsulins, PICIs, and GTAs. Abelardo Aguilar from the Luque Lab at the University of Miami created this 21.5 MB collection, last updated on 2026-04-28.

Use Cases

• Constructing phylogenetic trees based on maximum-likelihood inference outputs for HK97-fold proteins.
• Analyzing protein structure evolution based on PDB and AlphaFold-predicted models.
• Comparing sequence and structure-based phylogenies across viruses, encapsulins, PICIs, and GTAs.
• Identifying and classifying environmental viral major capsid proteins based on the provided FASTA sequence set.

Strengths

• Includes both experimentally resolved PDB structures and AlphaFold-predicted models with confidence assessments.
• Provides phylogenetic results from both sequence-based and structure-based analyses for comparative study.
• Covers a range of HK97-fold systems including viruses, encapsulins, PICIs, GTAs, and environmental viral-like entities.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Luque Lab, Department of Biology, University of Miami

Collection Method

Processed outputs from evolutionary analyses reported in an associated manuscript.

Freshness

Last updated 2026-04-28 05:55:42; freshness should be verified.