Antimicrobial Binding to the 30S Ribosomal Subunit in Borrelia burgdorferi

Swati R. Manjari's dataset, last updated in April 2026, comprises structural data for analyzing how medically important antimicrobials (MIAs) bind to the 30S ribosomal subunit of the bacterial pathogen Borrelia burgdorferi. The 4.0 MB collection of PDB files results from a comprehensive analysis of previously reported high-resolution structures and computational predictions. This work aims to support the structure-guided design of narrow-spectrum antimicrobials targeting specific pathogens.

Use Cases

• Predicting antibiotic binding sites based on structural analogy and energy minimization methods described.
• Analyzing conformational sensitivity in binding free energy computations for MIAs.
• Supporting structure-guided design of narrow-spectrum antimicrobials based on ribosomal target analysis.
• Comparing MIA binding variability across bacterial ribosome structures.

Strengths

• Dataset size is precisely 4.0 MB, indicating a focused and manageable collection.
• Data is derived from more than two decades of high-resolution structural studies, providing a historical foundation.
• Includes computational predictions for a specific pathogen (Borrelia burgdorferi) where no experimental MIA-bound structure was reported.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect temporal or methodological bias inherent to the analyzed historical structures.

Provenance

Source

figshare, authored by Swati R. Manjari.

Collection Method

Analysis of previously reported high-resolution ribosome structures, combined with computational methods including structural analogy, restrained energy minimization, and single-point binding free energy computations.

Time Range

Covers structural studies from more than two decades prior to the 2026 update.

Freshness

Last updated 2026-04-30 15:04:50; freshness should be verified.

Geography

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