Human Cancer Models Initiative: Next-Generation Tumor Models with Genomic Data

The Human Cancer Models Initiative (HCMI) is an international consortium generating novel, tumor-derived culture models annotated with genomic and clinical data. The National Cancer Institute supports four Cancer Model Development Centers tasked with producing these models from clinical samples, including rare tumor types and those from underrepresented populations. These models and their related data are available as a community resource.

Use Cases

• Developing targeted cancer therapies based on genomic annotations of tumor models.
• Studying rare cancer types based on the inclusion of rare tumor models.
• Investigating cancer in underrepresented populations based on models originating from those patients.
• Benchmarking cancer model tools based on the availability of next-generation culture models.

Strengths

• Models are derived from clinical samples, including rare tumor types and those from underrepresented populations.
• Models are annotated with both clinical and genomic data.
• Stringent internal quality control measures are used to ensure clinical and molecular integrity.

Limitations

• Row count, file formats, and column-level documentation are unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Center for Translational Data Science at The University of Chicago

Collection Method

Generated by Cancer Model Development Centers from clinical samples.

Time Range

unknown

Freshness

Last updated: unknown

Geography

unknown