Gut Microbiome Response to Acesulfame K Sweetener in a Dynamic Simulator

A 26.5 KB Excel dataset from figshare details the dose-dependent effects of the sweetener Acesulfame K on children's gut microbiota. Author Alicia Bellanco's study, updated in April 2026, observed increased taxa like Anaerostipes and Bacteroides thetaiotaomicron, correlated butyrate production, and a decrease in epithelial cell integrity. The data likely contains results from metataxonomic, metagenomic, and metabolic activity analyses performed in a dynamic gut simulator.

Use Cases

• Modeling dose-response relationships between Acesulfame K and specific bacterial taxa like Anaerostipes and Coprococcus.
• Investigating correlations between sweetener consumption and microbial butyrate production via the butanoyl-CoA pathway.
• Assessing potential risks to intestinal barrier function based on sulfated metabolite release data.
• Analyzing sulfatase and amidase enzyme activities in gut bacteria capable of degrading Acesulfame K.

Strengths

• Data originates from a controlled experimental setup using a dynamic gut simulator.
• Includes multi-omics analyses: metataxonomics, metagenomics, and metabolic activity.
• File is a manageable 26.5 KB XLSX, facilitating quick inspection.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (26.5 KB), indicating limited scope, likely summary results rather than raw sequencing data.
• Data reflects a specific experimental model (children's gut microbiota in a simulator) which may not generalize.

Provenance

Source

figshare, author Alicia Bellanco

Collection Method

Experimental study evaluating dose-dependent effects in a dynamic gut simulator.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-21 16:12:39; freshness should be verified.

Geography

Geographic origin of the children's gut microbiota samples is not specified.