HCN4 Ion Channel: Structure and Drug Target Data

HCN4 is one of four hyperpolarisation activated cyclic nucleotide gated ion channels responsible for the pacemaker current in the heart. The dataset likely contains structural data for HCN4, solved both in complex with cyclic AMP and without nucleotide, with 86% identity to the related HCN1 channel. This information supports the design of selective small molecule inhibitors for treating cardiac arrhythmias and pain.

Use Cases

• [Designing selective small molecule inhibitors] based on [comparison of HCN4 structure with HCN1 (86% identity)]
• [Studying cardiac arrhythmia mechanisms] based on [HCN4's role in the pacemaker current and known mutations]
• [Evaluating drug target specificity] based on [data on the non-selective drug ivabradine affecting all HCN channels]
• [Investigating cyclic nucleotide binding] based on [structures solved with and without cyclic AMP]

Strengths

• Provides specific structural data for the HCN4 ion channel, a key cardiac drug target.
• Includes comparative analysis with a closely related channel (HCN1) at 86% sequence identity.
• Dataset is associated with research from a recognized institution (University of Oxford).

Limitations

• Key metadata such as row count, column names, and specific file formats are unknown.
• The dataset's freshness and last update date are not provided.
• Descriptions are repeated across sources, offering no additional detail on data scale or granularity.

Provenance

Source

C.A. Shintre, University of Oxford