Human Inner Ear Transcriptome RNA-Seq Data from 2016 Study

2016 RNA-seq data profiles gene expression in adult human inner ear tissues, including cochlea, ampulla, saccule, and utricle. The dataset quantifies expression for over 50,000 predicted genes corresponding to approximately 200,000 transcripts. It was generated by Schrauwen et al. and archived on figshare for long-term accessibility.

Use Cases

• Identify genes preferentially expressed in cochlea versus vestibular organs like the ampulla, saccule, and utricle using transcript expression data.
• Analyze expression patterns of known hearing-loss genes across the profiled inner ear tissues.
• Characterize long non-coding RNAs and pseudogenes from the catalogue of over 200,000 transcripts.
• Investigate transcripts subject to nonsense-mediated decay within the human inner ear transcriptome.
• Map candidate genes within unmapped non-syndromic deafness loci using the high-resolution gene expression data.

Strengths

• Profiles expression for over 50,000 predicted genes, corresponding to approximately 200,000 transcripts.
• Includes data from multiple specific inner ear tissues: cochlea, ampulla, saccule, and utricle.
• Archived for long-term accessibility with a CC BY 4.0 license, ensuring reproducibility.

Limitations

• Data is from 2016 and may not reflect the latest genomic annotations or discoveries.
• Sample size and specific row count are unknown, limiting statistical power assessments.
• Derived from individuals without hearing impairment, limiting applicability to hearing loss pathology studies.

Provenance

Source

Schrauwen I. et al., Hearing Research, 2016;333:266–274.

Collection Method

RNA-sequencing transcriptomic profiling of adult human inner ear tissues.

Time Range

2016

Freshness

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Geography

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