Drosophila Survival Rates Under SOD1 Mutation and BMAA Neurotoxin Treatment

Survival rates of 35 day-old male sod1 transgenic flies treated with 3 mM BMAA neurotoxin. The dataset compares flies expressing mutant human A4V, G85R, and wild type SOD1 proteins, showing percentage increases in 50% survival rates. Data was contributed by author R. Islam and sourced from the paperswithcode platform.

Use Cases

• Compare survival outcomes based on different SOD1 protein mutations (A4V, G85R, wild type).
• Analyze the neurotoxic effect of BMAA treatment on motor neuron and glial cell models.
• Model dose-response relationships for survival rates under a specific 3 mM BMAA concentration.
• Benchmark genetic intervention effects using the reported 8%, 30%, and 15% survival rate increases.

Strengths

• Reports specific, quantified survival rate increases of 8%, 30%, and 15% for different SOD1 variants.
• Experimental conditions are clearly defined, including fly age (35 days), sex (male), and treatment concentration (3 mM BMAA).
• Includes statistical significance testing, as indicated by the mention of p-values.

Limitations

• Row count and full data table structure are unknown; column-level documentation is absent.
• Last update date is unknown; freshness unverified.
• The sample size per condition is limited to 10 flies per vial, which may affect statistical power.

Provenance

Source

paperswithcode

Collection Method

Likely experimental data from a biological study involving Drosophila melanogaster.