Human SOD1 in Flies: Survival Rates Under BMAA Treatment

R. Islam's dataset shows survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment. The data includes 10 flies per vial across three panels expressing mutant human A4V, G85R, and wild type SOD1 proteins. The 50% survival rate increased by 10%, 30%, and 30% for A4V, G85R, and wt SOD1 flies, respectively, compared to controls.

Use Cases

• Compare survival curves between different SOD1 genotypes based on the described A4V, G85R, and wild type panels.
• Model the neuroprotective effect of SOD1 overexpression based on the reported 10-30% increases in 50% survival rate.
• Analyze dose-response relationships in fly models using the described 3 mM BMAA treatment condition.
• Validate statistical significance of survival differences based on the p-value criteria mentioned in the description.

Strengths

• Data includes specific survival rate increases of 10%, 30%, and 30% for different SOD1 genotypes.
• Experimental conditions are detailed, including fly age (35 days), treatment concentration (3 mM BMAA), and sample size (10 flies per vial).
• Results are compared against two control groups (CS and dSOD1 flies), providing a basis for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Likely experimental data from a research study on SOD1 and BMAA toxicity in a Drosophila model.