Drosophila Survival Rates Under BMAA Treatment with Human SOD1 Mutations

R. Islam's dataset from paperswithcode shows survival rates of 35 day-old male transgenic Drosophila flies expressing mutant human SOD1 proteins (A4V, G85R, and wild type) under 3 mM BMAA treatment. The data indicates that SOD1-expressing flies survived longer than control flies, with 50% survival rates increased by 10%, 30%, and 30% for A4V, G85R, and wt SOD1, respectively, compared to dSOD1 controls. Statistical significance for differences is noted.

Use Cases

• Compare survival curves between different human SOD1 mutations (A4V, G85R, wild type) based on the described experimental panels.
• Analyze the neuroprotective effect of SOD1 expression against BMAA toxicity based on the reported increase in 50% survival rates.
• Validate statistical significance of survival differences in Drosophila models of neurodegeneration based on the mentioned p-value criteria.

Strengths

• Survival data is quantified with specific percentage increases (10%, 30%, 30%) for different SOD1 genotypes.
• Experimental conditions are clearly defined, including fly age (35 days), sex (male), and BMAA concentration (3 mM).
• Data includes comparisons to two control groups (CS and dSOD1), providing a basis for relative analysis.

Limitations

• The underlying data table, including column definitions and raw survival timepoints, is unavailable.
• The dataset's row count and complete temporal coverage are unknown.
• Metadata such as last update date and organizational source is missing.

Provenance

Source

R. Islam via paperswithcode

Collection Method

Likely experimental data from a biological study involving transgenic Drosophila.