Drosophila Survival Rates Under BMAA Treatment with Human SOD1 Expression

Survival rates of 5 day-old male transgenic flies under 3 mM BMAA treatment, with 10 flies per vial. The data compares flies expressing mutant human A4V, G85R, and wild type SOD1 proteins against control flies, showing increased longevity of 33%, 41%, and 66% at the 50% survival rate. The dataset originates from research by R. Islam and is shared via the paperswithcode platform.

Use Cases

• Compare survival curves between different SOD1 genotypes based on the described experimental groups.
• Analyze the neuroprotective effect of human SOD1 expression against BMAA toxicity based on the reported longevity increases.
• Validate statistical significance of survival differences based on the p-value thresholds mentioned in the description.

Strengths

• Experimental design includes specific treatment conditions (3 mM BMAA) and a defined sample size (10 flies per vial).
• Results report quantitative longevity increases (33%, 41%, 66%) at the 50% survival rate for different genotypes.
• Statistical significance testing is mentioned, with specific p-value thresholds (p<0.05, p<0.01, p<0.001).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

R. Islam via paperswithcode

Collection Method

Likely contains experimental data from a controlled laboratory study using Drosophila melanogaster.