Alzheimer's Neuropathology in Carnivore Species Compared to Humans

A summary of publications describing amyloid-beta and tau neuropathology in carnivores, collated by Brier A. Rigby Dames at the University of Bath. The data compares the occurrence, age, and prevalence of plaques and tauopathy in species like dogs and cats to humans. Key findings include that dogs, but not cats, have Alzheimer-like mature senile plaques.

Use Cases

• Compare Alzheimer-like neuropathology prevalence between carnivore species and humans based on reported occurrence data.
• Analyze the relationship between age and pathology onset in different species based on the reported age of occurrence.
• Investigate differences in cerebral amyloid angiopathy (CAA) and hyperphosphorylated tau between cats and dogs based on the collated observations.

Strengths

• Data is derived from a collation of relevant scientific publications.
• Includes specific comparisons between species, such as dogs having mature senile plaques while cats do not.
• Reports on multiple pathology types: Aβ deposits, CAA, tauopathy, NFTs, and pTau.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

University of Bath

Collection Method

Collated from relevant scientific publications.