Images and data from a 2026 iScience publication by Prowse et al. The collection includes western blots of wild-type and mutant huntingtin expression in engineered human embryonic stem cells and live-cell imaging of BDNF endosomes and lysosomes in derived forebrain neurons. The dataset was authored by Adam G. Hendricks and last updated in April 2026.
Use Cases
- Quantify huntingtin expression levels based on western blot images for different polyglutamine expansion lengths.
- Analyze BDNF endosome and lysosome motility patterns based on live-cell imaging data in forebrain neurons.
- Model the relationship between polyglutamine repeat length and axonal transport perturbation based on the experimental data.
- Validate computational models of neurodegenerative disease pathology based on the provided imaging and biochemical data.
Strengths
- Includes both biochemical (western blot) and dynamic cellular (live-cell imaging) data modalities.
- Data is directly associated with a peer-reviewed 2026 publication in iScience.
- Covers a range of polyglutamine expansion lengths in a controlled hESC model system.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count and overall dataset size are unknown, which may limit suitability assessment.
- Description metadata is limited; actual data quality requires manual inspection after download.
Provenance
- Source
- Prowse et al., iScience, 2026.
- Collection Method
- Experimental data from western blotting and live-cell imaging of engineered hESCs and derived neurons.
- Time Range
- 2026
- Freshness
- Last updated 2026-04 04:12:24; freshness should be verified.
- Geography
- null