SULT2B1b Gene Expression and Hepatocellular Carcinoma Cell Proliferation Data

Research data from Shanghai Medical College of Fudan University investigates the role of hydroxysteroid sulfotransferase SULT2B1b in hepatocellular carcinoma. The study includes findings from human tumorous tissues, mouse cell line Hepa1-6, and human cell lines Huh-7, Hep3B, SMMC-7721, and BEL-7402. Experiments assessed cell growth, apoptosis, and gene expression in vitro and in nude mouse xenografts.

Use Cases

• Analyzing the correlation between SULT2B1b expression levels and hepatocellular carcinoma cell proliferation rates based on the described cell line experiments.
• Investigating the impact of SULT2B1b knockdown on cell-cycle arrest and apoptosis based on described changes in FAS, cyclinB1, BCL2, and MYC expression.
• Modeling tumor growth suppression in xenograft models based on the described in vivo experiments with SULT2B1b interference.

Strengths

• Data is derived from experiments on multiple human hepatocarcinoma cell lines (Huh-7, Hep3B, SMMC-7721, BEL-7402) and a mouse cell line (Hepa1-6).
• Findings are supported by both in vitro and in vivo (nude mouse xenograft) experimental models.
• Analysis includes both transcript and protein level measurements for key genes like FAS, cyclinB1, BCL2, and MYC.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Xiaoming Yang, Shanghai Medical College of Fudan University

Collection Method

Experimental research data from cell culture and animal models, likely published in a scientific paper.