Impatiens macrantha Phytochemical Analysis with α-Glucosidase Inhibition Data

A phytochemical study of Impatiens macrantha isolated a new biflavan and nine known compounds. The new compound, macranthabiflavan A, exhibited potent α-glucosidase inhibitory activity with an IC50 of 13.08 μg/mL, stronger than the control acarbose. Molecular docking analysis revealed its binding affinity and mechanism of action.

Use Cases

• Benchmarking α-glucosidase inhibitors based on the reported IC50 values for isolated compounds.
• Validating molecular docking models based on the reported binding affinity and catalytic pocket interactions.
• Identifying potential lead compounds for diabetes research based on the described inhibitory activity.
• Comparing spectroscopic data for structure elucidation of biflavans based on the described 1D- and 2D-NMR analyses.

Strengths

• Includes a specific IC50 value (13.08 ± 0.16 μg/mL) for the primary compound's bioactivity.
• Provides a comparative benchmark with a positive control (acarbose IC50 197.5 ± 6.25 μg/mL).
• Reports a concrete molecular docking result (binding affinity of -7.299 kcal/mol).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained in DOC/PDF files, which are less structured for direct computational analysis than tabular formats.

Provenance

Source

figshare

Collection Method

Laboratory isolation and spectroscopic analysis, followed by enzymatic assay and computational docking.

Time Range

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Freshness

Last updated 2026-04-30 14:40:03; freshness should be verified.

Geography

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