Ficus Ottoniifolia Leaf Extract Effects on CFA-Induced Arthritis in Rats

A pharmacological study by ThankGod Mmaduabuchi Ogbonna, uploaded in 2026, evaluates the therapeutic potential of a plant extract. The research involved 30 albino rats divided into six groups and treated over 21 days. It measured dose-dependent effects on antioxidant enzymes and pro-inflammatory cytokines following arthritis induction.

Use Cases

• Benchmarking natural extract efficacy based on measured antioxidant parameters (SOD, CAT, GPx, GSH).
• Analyzing dose-response relationships in animal models based on treatment groups (200, 400, 600 mg/kg).
• Comparing novel treatments to standard drugs based on pro-inflammatory cytokine levels (IL-1, IL-6, TNF-α).

Strengths

• Study design includes a standard drug control group (diclofenac) for comparison.
• Clear dose-dependent results are reported across three extract concentrations.
• Multiple biochemical endpoints are measured, including four antioxidant markers and three cytokines.

Limitations

• The dataset is a 197.8 KB document (PDF/DOCX); the underlying numerical data is not provided in a structured, machine-readable format.
• Row count and column-level documentation are absent, limiting suitability assessment for direct analysis.
• The data is from a single animal study, which may limit generalizability.

Provenance

Source

ThankGod Mmaduabuchi Ogbonna via figshare

Collection Method

Experimental study involving 30 albino rats with CFA-induced arthritis, treated with plant extract for 21 days.

Freshness

Last updated 2026-06-02 11:41:28.